Determination of antidiabetic compounds from Helicteres isora fruits by oral glucose tolerance test
نویسندگان
چکیده
منابع مشابه
Antioxidant and Antidiabetic Activity of Helicteres isora (L.) Fruits
The present investigations evaluated the antioxidant and antidiabetic activity of Helicteres isora (L.) fruits belonging to the family Sterculiaceae. The hot water extract of Helicteres isora fruits was prepared and screened for its in vitro antioxidant activity using 1,1-diphenyl,2-picryl hydrazyl assay, ss-carotene-linoleate model and microsomal lipid peroxidation or thiobarbituric acid react...
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Insulin receptor (IR) proteins were essential intracellular signaling peptides in the insulin action cascade. Insulin receptor substrate proteins (IRS-1and IRS-2) serve and regulate the insulin level in the normal insulin action. The broad role of IRS-1 and IRS-2 in cell growth and survival reveals a common regulatory pathway linking development, somatic growth, fertility, neuronal proliferatio...
متن کاملStudy of glucose uptake activity of Helicteres isora Linn. fruits in L-6 cell lines
The effect of hot water extract of fruits of Helicteres isora on glucose uptake was studied in rodent skeletal muscle cells (L-6 cells) involved in glucose utilization. H. isora is an antidiabetic medicinal plant being used in Indian traditional medicine. Hot water extracts were analysed for glucose uptake activity and found to be significantly active at 200 mug/ml dose comparable with insulin ...
متن کاملPotential of enhancing tumor toxicity by crude ethanolic extracts of fruits of Helicteres isora (L.)
Objective: The present study was aimed to evaluate therapeutic potential of Helicteres isora (L.) which holds the potential of an anticancer drug. Methods: We have examined the anticancer properties of ethanolic extract of fruits of H. isora on two cancer cell lines from different origins with different p53 status namely, MCF7 and HT29. Different in vitro cell assays were conducted to evaluate ...
متن کاملAntibacterial & antiplasmid activities of Helicteres isora L.
BACKGROUND & OBJECTIVES The multiple drug resistance (MDR) is a serious health problem and major challenge to the global drug discovery programmes. Most of the genetic determinants that confer resistance to antibiotics are located on R-plasmids in bacteria. The present investigation was undertaken to investigate the ability of organic extract of the fruits of Helicteres isora to cure R-plasmids...
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ژورنال
عنوان ژورنال: Journal of Applied Pharmaceutical Science
سال: 2016
ISSN: 2231-3354
DOI: 10.7324/japs.2016.60227